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EXOSOME

Exosomes are tiny extracellular vesicles with a diameter of approximately 30 to 150 nanometers, enclosed in a lipid bilayer membrane. They contain various biomolecules, including growth factors, miRNA, mRNA and lipids. Exosomes secreted by mesenchymal stem cells can modulate the physiological and metabolic processes of recipient cells, such as regulating immune responses, promoting cell growth and differentiation, and coordinating tissue repair and regeneration. 

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Image by Pavel Marianov

new era of Exosomes

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Stem Cell Derived Nano Particles

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01 Collection

Mesenchymal stem cells, MSC are cultured in culture medium under specific conditions to promote exosomes secretion, and then culture medium supernatant is collected. 

02 Isolation

Exosomes are isolated from the MSC culture media using specialized equipment such as ultracentrifuges or tangential flow filtration systems, which separate the exosomes from other cellular debris based on size and density.

03 Purification

The isolated exosomes are  purified using advanced techniques such as the size-exclusion chromatography, which separates the exosomes based on their size and surface markers, resulting in highly pure exosome preparations.

04 Cryopreservation

Once the exosomes reach the desired purity and concentration, they can be cryopreserved using advanced techniques such as controlled-rate freezing, which ensure that the exosomes remain viable and functional during long-term storage at ultra-low temperatures.

ROLE OF EXOSOMES IN COSMETICS

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01. Facial Rejuvenation

Exosomes are gaining traction in non-surgical facial rejuvenation, offering a natural and minimally invasive alternative to traditional cosmetic procedures. Their ability to stimulate collagen production and enhance skin texture makes them an ideal choice for those seeking a radiant and youthful complexion without the downtime associated with surgery.

02. Hair Restoration

Studies indicate that exosome therapy may stimulate hair follicles, promoting hair growth and addressing concerns related to hair thinning or loss. This innovative approach holds great potential for individuals seeking non-invasive solutions for hair restoration.

03. Scar Reduction  

Exosomes play a pivotal role in tissue regeneration, making them invaluable in scar reduction and skin repair. Their capacity to modulate cellular communication contributes to the healing process, resulting in improved skin texture and a reduction in the appearance of scars.

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